The Resource for your Nonhuman Primate Research

We support innovation, reproducibility, and translation of preclinical research with high-quality biological development. We offer primate antibodies and recombinant proteins for pre-clinical NHP studies, NHP-specific reagents for in vitro assays, and have an industry wide antibody reactivity database for NHP species.

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NHP Reactivity

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2025 February 04

Interleukin-21 and anti-a4ß7 dual therapy during ART promotes immunological and microbiome responses in SIV-infected macaques.

Johnson, Samuel D Pino, Maria Acharya, Arpan Clain, Julien A Bose, Deepanwita Nguyen, Kevin Harper, Justin Villinger, Francois Paiardini, Mirko Byrareddy, Siddappa N

JCI Insight

Anti-alpha4/beta7 [A4B7R1] Anti-alpha4/beta7 [A4B7R1]-PE

2025 January 31

Rhesus Cytomegalovirus-encoded Fc?-binding glycoproteins facilitate viral evasion from IgG-mediated humoral immunity.

Otero, Claire E Petkova, Sophia Ebermann, Martin Taher, Husam John, Nessy Hoffmann, Katja Davalos, Angel Moström, Matilda J Gilbride, Roxanne M Papen, Courtney R Barber-Axthelm, Aaron Scheef, Elizabeth A Barfield, Richard Sprehe, Lesli M Kendall, Savannah Manuel, Tabitha D Beechwood, Teresa Nguyen, Linh Khanh Vande Burgt, Nathan H Chan, Cliburn Denton, Michael Streblow, Zachary J Streblow, Daniel N Tarantal, Alice F Hansen, Scott G Kaur, Amitinder Permar, Sallie Früh, Klaus Hengel, Hartmut Malouli, Daniel Kolb, Philipp

Nat Commun

Anti-CD4 [CD4R1]

2025 January 22

Cardiac allograft tolerance can be achieved in nonhuman primates by donor bone marrow and kidney cotransplantation.

Tonsho, Makoto O, Jane M Ahrens, Kaitlan Robinson, Kortney Sommer, Wiebke Boskovic, Svjetlan Patel, Parth M Becerra, David C Huh, Kyu Ha Miller, Cynthia L Dehnadi, Abbas Hanekamp, Isabel Rosales, Ivy A Colvin, Robert B Sachs, David H Alessandrini, Alessandro Cosimi, A Fairchild, Robert L Cravedi, Paolo Bin, Sofia Heeger, Peter S Allan, James S Kawai, Tatsuo Benichou, Gilles Madsen, Joren C

Sci Transl Med

Anti-CD154 [5C8H1] Anti-CD8 alpha [MT807R1]

2025 January 09

Enhanced Costimulation Blockade With aCD154, aCD2, and aCD28 to Promote Heart Allograft Tolerance in Nonhuman Primates.

Chaban, Ryan Ileka, Ikechukwu Kinoshita, Kohei McGrath, Gannon Habibabady, Zahra Ma, Madelyn Diaz, Victoria Maenaka, Akihiro Rosales, Ivy Lederman, Seth Tkachev, Victor Madsen, Joren C Pierson, Richard N

Transplantation

Anti-CD2 [LoCD2bR1]

News & Updates:

2024 Aug 23

mAbsolve Parnership for Fc-silenced STR Antibodies

Today, we celebrate a milestone—partnering with mAbsolve to incorporate ‘STR’ mutations into our antibodies. This ensures targeted action without unintended immune responses, boosting rigor, effectiveness, and safety. By decreasing Fc-mediated interference (hello Fc-block!) and enhancing the signal-to-noise ratio, STR-enhanced antibodies will produce more robust and reproducible scientific findings. Expect many STR-enhanced antibodies soon!

READ MORE

2024 Apr 09

For your Acknowledgements section

Reagents used in these studies were provided by the NIH Nonhuman Primate Reagent Resource (P40 OD028116, U24 AI126683).

2024 Apr 11

NHPRR Linkedin

Follow our newest publications, products, and messages on LinkedIn!

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2024 Apr 09

RRID Citation on Materials and Methods

For your Materials & Methods section: The rhesus recombinant Anti-CD8 beta [CD8b255R1] monoclonal antibody was engineered and produced by the Nonhuman Primate Reagent Resource (NIH Nonhuman Primate Reagent Resource Cat# PR-2557, RRID:AB_2716321)

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Sharing Your Data: Our community-based reactivity database is built by users like you. Share your results!

Requesting a Reagent: We develop NHP-specific antibodies based on investigator-initiated requests, including: recombinant proteins for cell depletion, receptor activation, cytokine neutralization, co-stimulatory blockade, immunosuppression.

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Sharing Your Publication: If you’ve recently published a study using an NHPRR reagent, add it to the publication database.