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Publications Using Our Reagents

See publications using our reagents to inform your research. If you have recently published a study using a NHPRR reagent, you can now add submit it directly to the publication database.

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2022 January 04

Potent anti-viral activity of a trispecific HIV neutralizing antibody in SHIV-infected monkeys

Amarendra Pegu, Ling Xu, Megan E DeMouth, Giulia Fabozzi, Kylie March, Cassandra G Almasri, Michelle D Cully, Keyun Wang, Eun Sung Yang, Joana Dias, Christine M Fennessey, Jason Hataye, Ronnie R Wei, Ercole Rao, Joseph P Casazza, Wanwisa Promsote, Mangaiarkarasi Asokan, Krisha McKee, Stephen D Schmidt, Xuejun Chen, Cuiping Liu, Wei Shi, Hui Geng, Kathryn E Foulds, Shing-Fen Kao, Amy Noe, Hui Li, George M Shaw, Tongqing Zhou, Constantinos Petrovas, John-Paul Todd, Brandon F Keele, Jeffrey D Lifson, Nicole A Doria-Rose, Richard A Koup, Zhi-Yong Yang, Gary J Nabel, John R Mascola

Cell Rep

Anti-CD8 beta [CD8b255R1]

2021 December 23

Anti-thymoglobulin induction improves neonatal porcine xenoislet engraftment and survival

Gao Qimeng, Davis Robert, Fitch Zachary, Mulvihill Michael, Ezekian Brian, Schroder Paul, Schmitz Robin, Song Mingqing, Leopardi Frank, Ribeiro Marianna, Miller Allison, Moris Dimitrios, Shaw Brian, Samy Kannan, Reimann Keith, Williams Kyha, Collins Bradley, Kirk Allan

Xenotransplantation

Anti-rhesus thymocyte [rhATG] - (all lots)

2021 December 07

Production and Characterization of SIV-Specific CAR/CXCR5 T Cells

Mary S. Pampusch, Agnes Hajduczki, Gwantwa Mwakalundwa, Elizabeth Connick, Edward A. Berger, Pamela J. Skinner

Immune Receptors. Methods in Molecular Biology, vol 2421. Humana, New York, NY.

Anti-CXCR5 [710D82.1]

2021 December 03

A particulate saponin/TLR agonist vaccine adjuvant alters lymph flow and modulates adaptive immunity

Murillo Silva, Yu Kato, Mariane B Melo, Ivy Phung, Brian L Freeman, Zhongming Li, Kangsan Roh, Jan W Van Wijnbergen, Hannah Watkins, Chiamaka A Enemuo, Brittany L Hartwell, Jason Y H Chang, Shuhao Xiao, Kristen A Rodrigues, Kimberly M Cirelli, Na Li, Sonya Haupt, Aereas Aung, Benjamin Cossette, Wuhbet Abraham, Swati Kataria, Raiza Bastidas, Jinal Bhiman, Caitlyn Linde, Nathaniel I Bloom, Bettina Groschel, Erik Georgeson, Nicole Phelps, Ayush Thomas, Julia Bals, Diane G Carnathan, Daniel Lingwood, Dennis R Burton, Galit Alter, Timothy P Padera, Angela M Belcher, William R Schief, Guido Silvestri, Ruth M Ruprecht, Shane Crotty, Darrell J Irvine

Sci Immunol

Anti-CD38 [OKT10]-PE

2021 November 24

SARS-CoV-2 Infection of Rhesus Macaques Treated Early with Human COVID-19 Convalescent Plasma

Jesse D Deere, Timothy D Carroll, Joseph Dutra, Linda Fritts, Rebecca Lee Sammak, JoAnn L Yee, Katherine J Olstad, J Rachel Reader, Amy Kistler, Jack Kamm, Clara Di Germanio, Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Graham Simmons, Jennifer Watanabe, Rachel E Pollard, Jodie Usachenko, Ramya Immareddy, Brian A Schmidt, Shelby L O'Connor, Joseph DeRisi, Michael P Busch, Smita S Iyer, Koen K A Van Rompay, Dennis J Hartigan-O'Connor, Christopher J Miller

Microbiol Spectr

Anti-SARS-CoV Spike [CR3022]

2021 November 22

Robust IgM responses following intravenous vaccination with Bacille Calmette–Guérin associate with prevention of Mycobacterium tuberculosis infection in macaques

Edward B. Irvine, Anthony O’Neil, Patricia A. Darrah, Sally Shin, Alok Choudhary, Wenjun Li, William Honnen, Smriti Mehra, Deepak Kaushal, Hannah Priyadarshini Gideon, JoAnne L. Flynn, Mario Roederer, Robert A. Seder, Abraham Pinter, Sarah Fortune & Galit Alter

Nature Immunology

Anti-rhesus IgA [9B9] Anti-rhesus IgG1 [ena]

2021 November 18

Optimization of Non-Coding Regions for a Non-Modified mRNA COVID-19 Vaccine

Makda S. Gebre, Susanne Rauch, Nicole Roth, Jingyou Yu, Abishek Chandrashekar, Noe B. Mercado, Xuan He, Jinyan Liu, Katherine McMahan, Amanda Martinot, David R. Martinez, Tori Giffin, David Hope, Shivani Patel, Daniel Sellers, Owen Sanborn, Julia Barrett, Xiaowen Liu, Andrew C. Cole, Laurent Pessaint, Daniel Valentin, Zack Flinchbaugh, Jake Yalley-Ogunro, Jeanne Muench, Renita Brown, Anthony Cook, Elyse Teow, Hanne Andersen, Mark G. Lewis, Adrianus C. M. Boon, Ralph S. Baric, Stefan O. Mueller, Benjamin Petsch & Dan H. Barouch

Nature

Anti-rhesus IgG1/3 [1B3]-HRP

2021 November 08

Early Interferon-Gamma Response in Nonhuman Primate Recipients of Solid-Organ Xenotransplantation

Eun Mi Park, Haneulnari Lee, Hee Jung Kang, Keon Bong Oh, Jun Seok Kim, Hyun Keun Chee, Jung-Hwan Park, Kyoung Sik Park, Ik-Jin Yun

Transplantation Proceedings

Anti-CD154 [5C8H1]

2021 November 05

Diphtheria Toxin Based Bivalent Anti-cMPL Immunotoxin Effectively Depletes Human Hematopoietic Stem and Progenitor Cells

Daisuke Araki, Diogo M. Magnani, Zhirui Wang, Richard H. Smith, Andre Larochelle

Blood (2021) 138 (Supplement 1): 3808

Anti-CD110 [CD110IT]-Diphtheria Toxin

2021 October 22

Long-term protective immunity induced by an adjuvant-containing live-attenuated AIDS virus

Tomotaka Okamura, Yuya Shimizu, Masamitsu N Asaka, Tomohiro Kanuma, Yusuke Tsujimura, Takuya Yamamoto, Kazuhiro Matsuo, Yasuhiro Yasutomi

NPJ Vaccines

Anti-CD8 alpha [MT807R1]

2021 October 12

Biophysical Evaluation of Rhesus Macaque Fc Gamma Receptors Reveals Similar IgG Fc Glycoform Preferences to Human Receptors

Andrew R. Crowley, Nana Yaw Osei-Owusu, Gillian Dekkers, Wenda Gao, Manfred Wuhrer, Diogo M. Magnani, Keith A. Reimann, Seth H. Pincus, Gestur Vidarsson and Margaret E. Ackerman

Front. Immunol.,

Anti-CD20 [2B8R1] Anti-CD20 [2B8R1F8]-Afucosylated

2021 September 21

Prior infection with SARS-CoV-2 WA1/2020 partially protects rhesus macaques against re-infection with B.1.1.7 and B.1.351 variants

Abishek Chandrashekar, Jinyan Liu, Jingyou Yu, Katherine McMahan, Lisa H Tostanoski, Catherine Jacob-Dolan, Noe B Mercado, Tochi Anioke, Aiquan Chang, Sarah Gardner, Victoria M Giffin, David L Hope, Felix Nampanya, Shivani Patel, Owen Sanborn, Daniel Sellers, Huahua Wan, Amanda J Martinot, John J Baczenas, Shelby L O'Connor, Laurent Pessaint, Daniel Valentin, Benjamin Espina, Lauren Wattay, Maria G Ferrari, Renita Brown, Anthony Cook, Deandre Bueno-Wilkerson, Elyse Teow, Hanne Andersen, Mark G Lewis, Dan H Barouch

Sci Transl Med

Anti-rhesus IgG1/3 [1B3]-HRP Anti-CD38 [OKT10]-PE

2021 September 15

C3 complement inhibition prevents antibody-mediated rejection and prolongs renal allograft survival in sensitized non-human primates

Robin Schmitz, Zachary W Fitch, Paul M Schroder, Ashley Y Choi, Miriam Manook, Janghoon Yoon, Mingqing Song, John S Yi, Sanjay Khandelwal, Gowthami M Arepally, Alton B Farris, Edimara S Reis, John D Lambris, Jean Kwun, Stuart J Knechtle

Nat Commun

Anti-rhesus thymocyte [rhATG] - (all lots)

2021 September 07

IL-21 Enhances Influenza Vaccine Responses in Aged Macaques with Suppressed SIV

Daniel Kvistad, Suresh Pallikkuth, Tirupataiah Sirupangi, Rajendra Pahwa, Alexander Kizhner, Constantinos Petrovas, Francois Villinger, and Savita Pahwa

JCI Insight

Anti-alpha4/beta7 [A4B7R1]

2021 September 03

The Growth of Xenotransplanted Hearts Can Be Reduced with Growth Hormone Receptor Knockout Pig Donors

Corbin E.Goerlich, Bartley Griffith, Peter Hanna, Susie N.Hong, David Ayares, Avneesh K. Singh, Muhammad M.Mohiuddin

J Thorac Cardiovasc Surg

Anti-CD40 [2C10R4]

2021 August 24

Tandem bispecific antibody prevents pathogenic SHIV SF162P3CN infection and disease progression

Mengyue Niu, Yik Chun Wong, Hui Wang, Xin Li, Chun Yin Chan, Qi Zhang, Lijun Ling, Lin Cheng, Ruoke Wang, Yanhua Du, Lok Yan Yim, Xia Jin, Haoji Zhang, Linqi Zhang, Zhiwei Chen

Cell Rep.

Anti-CD8 beta [CD8b255R1]

2021 August 18

Blocking α 4 β 7 integrin delays viral rebound in SHIV SF162P3-infected macaques treated with anti-HIV broadly neutralizing antibodies

Ines Frank, Mariasole Cigoli, Muhammad S Arif, Marissa D Fahlberg, Stephanie Maldonado, Giulia Calenda, Amarendra Pegu, Eun Sung Yang, Reda Rawi, Gwo-Yu Chuang, Hui Geng, Cuiping Liu, Tongqing Zhou, Peter D Kwong, James Arthos, Claudia Cicala, Brooke F Grasperge, James L Blanchard, Agegnehu Gettie, Christine M Fennessey, Brandon F Keele, Monica Vaccari, Thomas J Hope, Anthony S Fauci, John R Mascola, Elena Martinelli

Sci Transl Med

Anti-alpha4/beta7 [A4B7R1]

2021 August 13

Tomotherapy Applied Total Lymphoid Irradiation and Allogeneic Hematopoietic Cell Transplantation Generates Mixed Chimerism in the Rhesus Macaque Model

Lisa Forrest, John Fechner, Jennifer Post, Nathaniel Van Asselt, Kevin Kvasnica, Lynn D Haynes, Jenny Coonen, Kevin Brunner, W John Haynes, Christopher Little, William J Burlingham, Peiman Hematti, Samuel Strober, Dixon B Kaufman

Radiat Res

Anti-rhesus thymocyte [rhATG] - (all lots)

2021 July 19

Circulating integrin α4β7+ CD4 T cells are enriched for proliferative transcriptional programs in HIV infection

Yashavanth S. Lakshmanappa, Jamin W. Roh, Niharika N. Rane, Ashok R. Dinasarapu, Daphne D. Tran, Vijayakumar Velu, Anandi N. Sheth, Igho Ofotokun, Rama R. Amara, Colleen F. Kelley, Elaine Waetjen, Smita S. Iyer

FEBS Letters

Anti-alpha4/beta7 [A4B7R1]-APC Anti-alpha4/beta7 [A4B7R1]-PE

2021 July 02

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8cells.

Schouest B, Beddingfield BJ, Gilbert MH, Bohm RP, Schiro F, Aye PP, Panganiban AT, Magnani DM, Maness NJ

Virology

Anti-CD8 alpha [MT807R1]

2021 June 07

Antibody-based CCR5 blockade protects Macaques from mucosal SHIV transmission

Xiao L Chang, Gabriela M Webb, Helen L Wu, Justin M Greene, Shaheed Abdulhaqq, Katherine B Bateman, Jason S Reed, Cleiton Pessoa, Whitney C Weber, Nicholas Maier, Glen M Chew, Roxanne M Gilbride, Lina Gao, Rebecca Agnor, Travis Giobbi, Jeffrey Torgerson, Don Siess, Nicole Burnett, Miranda Fischer, Oriene Shiel, Cassandra Moats, Bruce Patterson, Kush Dhody, Scott Kelly, Nader Pourhassan, Diogo M Magnani, Jeremy Smedley, Benjamin N Bimber, Nancy L Haigwood, Scott G Hansen, Timothy R Brown, Lishomwa C Ndhlovu, Jonah B Sacha

Nat Commun

Anti-rhesus IgG1/3 [1B3]-HRP

2021 June 02

Measuring the Impact of Targeting FcRn-Mediated IgG Recycling on Donor-Specific Alloantibodies in a Sensitized NHP Model

Miriam Manook, Walter J. Flores, Robin Schmitz, Zachary Fitch, Janghoon Yoon, Yeeun Bae, Brian Shaw, Allan Kirk, Melissa Harnois, Sallie Permar, Alton B. Farris, Diogo M. Magnani, Jean Kwun and Stuart Knechtle

Front. Immunol.

Anti-FcRn [RozR1LALA]

2021 May 28

Non-neutralizing Antibodies May Contribute to Suppression of SIVmac239 Viremia in Indian Rhesus Macaques.

Pedreño-Lopez N, Rosen BC, Flores WJ, Gorman MJ, Voigt TB, Ricciardi MJ, Crosno K, Weisgrau KL, Parks CL, Lifson JD, Alter G, Rakasz EG, Magnani DM, Martins MA, Watkins DI

Frontiers in immunology

Anti-FcRn [RozR1LALA]

2021 May 21

A comparative study of human-and rhesus-specific antithymocyte globulins in Rhesus macaques

Brian I Shaw, Robin Schmitz, Walter J Flores, Diogo M Magnani, Jie Li, Mingqing Song, Allan D Kirk

Clin Transplant

Anti-rhesus thymocyte [rhATG] - (all lots)

2021 May 20

The immune landscape in tuberculosis reveals populations linked to disease and latency.

Esaulova E, Das S, Singh DK, Choreño-Parra JA, Swain A, Arthur L, Rangel-Moreno J, Ahmed M, Singh B, Gupta A, Fernández-López LA, de la Luz Garcia-Hernandez M, Bucsan A, Moodley C, Mehra S, García-Latorre E, Zuniga J, Atkinson J, Kaushal D, Artyomov MN, Khader SA

Cell host & microbe

Anti-CD38 [OKT10]-APC

2021 April 09

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8 + cells

Blake Schouest, Brandon J Beddingfield, Margaret H Gilbert, Rudolf P Bohm, Faith Schiro, Pyone P Aye, Antonito T Panganiban, Diogo M Magnani, Nicholas J Maness

Virology

Anti-CD8 alpha [MT807R1]

2021 March 15

Antibody-mediated depletion of viral reservoirs is limited in SIV-infected macaques treated early with antiretroviral therapy

Adrienne E Swanstrom, Taina T Immonen, Kelli Oswald, Cathi Pyle, James A Thomas, William J Bosche, Lorna Silipino, Michael Hull, Laura Newman, Vicky Coalter, Adam Wiles, Rodney Wiles, Jacob Kiser, David R Morcock, Rebecca Shoemaker, Randy Fast, Matthew W Breed|, Joshua Kramer, Duncan Donohue, Tyler Malys, Christine M Fennessey, Charles M Trubey, Claire Deleage, Jacob D Estes, Jeffrey D Lifson, Brandon F Keele, Gregory Q Del Prete

J Clin Invest

Anti-CD4 [CD4R1] Anti-CD38 [OKT10]-PE

2021 March 03

New SHIVs and Improved Design Strategy for Modeling HIV-1 Transmission, Immunopathogenesis, Prevention and Cure

Hui Li, Shuyi Wang, Fang-Hua Lee, Ryan S Roark, Alex I Murphy, Jessica Smith, Chengyan Zhao, Juliette Rando, Neha Chohan, Yu Ding, Eunlim Kim, Emily Lindemuth, Katharine J Bar, Ivona Pandrea, Cristian Apetrei, Brandon F Keele, Jeffrey D Lifson, Mark G Lewis, Thomas N Denny, Barton F Haynes, Beatrice H Hahn, George M Shaw

J Virol

Anti-CD8 beta [CD8b255R1] Anti-CD8 alpha [MT807R1]

2021 March 01

CD4+/CD8+ T cell ratio correlates with the graft fate in pig-to-nonhuman primate islet xenotransplantation

Hyunwoo Chung, Hyun-Je Kim, Jung-Sik Kim, Il-Hee Yoon, Byoung-Hoon Min, Jun-Seop Shin, Jong-Min Kim, Won-Woo Lee and Chung-Gyu Park

Xenotransplantation

Anti-CD40 [2C10R4] Anti-CD154 [5C8H1]

2021 February 17

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies.

Pedreño-Lopez N, Dang CM, Rosen BC, Ricciardi MJ, Bailey VK, Gutman MJ, Gonzalez-Nieto L, Pauthner MG, Le K, Song G, Andrabi R, Weisgrau KL, Pomplun N, Martinez-Navio JM, Fuchs SP, Wrammert J, Rakasz EG, Lifson JD, Martins MA, Burton DR, Watkins DI, Magnani DM

Molecular therapy. Methods & clinical development

Anti-CD8 beta [CD8b255R1]

2021 February 01

Mucosal integrin α4β7 blockade fails to reduce the seeding and size of viral reservoirs in SIV-infected rhesus macaques

Widade Ziani, Jiasheng Shao, Angela Fang, Patrick J Connolly, Xiaolei Wang, Ronald S Veazey, Huanbin Xu

FASEB J

Anti-alpha4/beta7 [A4B7R1]

2021 January 22

SARS-CoV-2 induces robust germinal center CD4 T follicular helper cell responses in rhesus macaques

Yashavanth Shaan Lakshmanappa, Sonny R Elizaldi, Jamin W Roh, Brian A Schmidt, Timothy D Carroll, Kourtney D Weaver, Justin C Smith, Anil Verma, Jesse D Deere, Joseph Dutra, Mars Stone, Sergej Franz, Rebecca Lee Sammak, Katherine J Olstad, J Rachel Reader, Zhong-Min Ma, Nancy K Nguyen, Jennifer Watanabe, Jodie Usachenko, Ramya Immareddy, JoAnn L Yee, Daniela Weiskopf, Alessandro Sette, Dennis Hartigan-O'Connor, Stephen J McSorley, John H Morrison, Nam K Tran, Graham Simmons, Michael P Busch, Pamela A Kozlowski, Koen K A Van Rompay, Christopher J Miller, Smita S Iyer

Nat Commun . 2021 Jan 22;12(1):541

Anti-rhesus IgA [10F12]

2021 January 13

Spatiotemporal single-cell profiling reveals that invasive and tissue-resident memory donor CD8 + T cells drive gastrointestinal acute graft-versus-host disease

Victor Tkachev, James Kaminski, E Lake Potter, Scott N Furlan, Alison Yu, Daniel J Hunt, Connor McGuckin, Hengqi Zheng, Lucrezia Colonna, Ulrike Gerdemann, Judith Carlson, Michelle Hoffman, Joe Olvera, Chris English, Audrey Baldessari, Angela Panoskaltsis-Mortari, Benjamin Watkins, Muna Qayed, Yvonne Suessmuth, Kayla Betz, Brandi Bratrude, Amelia Langston, John T Horan, Jose Ordovas-Montanes, Alex K Shalek, Bruce R Blazar, Mario Roederer, Leslie S Kean

Sci Transl Med

Anti-alpha4/beta7 [A4B7R1] Anti-Mamu A*01 [P12]-PE

2020 October 08

Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates

Blake J Rust, Leslie S Kean, Lucrezia Colonna, Katherine E Brandenstein, Nikhita H Poole, Willimark Obenza, Mark R Enstrom, Colby R Maldini, Gavin I Ellis, Christine M Fennessey, Meei-Li Huang, Brandon F Keele, Keith R Jerome, James L Riley, Hans-Peter Kiem, Christopher W Peterson

Blood

Anti-PD1 [NIVOR4LALA]

2020 September 05

Preoperative Carfilzomib and Lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model

Paul M Schroder , Robin Schmitz, Zachary W Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y Choi, Miriam Manook, Andrew Barbas, Frank Leopardi, Mingqing Song, Alton B Farris, Bradley Collins, Jean Kwun, Stuart J Knechtle

Kidney Int

Anti-rhesus thymocyte [rhATG] - (all lots)

2020 August 05

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Keith D Kauffman, Shunsuke Sakai, Nickiana E Lora, Sivaranjani Namasivayam, Paul J Baker, Olena Kamenyeva, Taylor W Foreman, Christine E Nelson, Deivide Oliveira-de-Souza, Caian L. Vinhaes, Ziv Yaniv, Cecilia S Lindestam Arleham, Alessandro Sette, Gordon J Freeman, Rashida Moore, the NIAID/DIR Tuberculosis Imaging Program, Alan Sher, Katrin D Mayer-Barber, Bruno B Andrade, Juraj Kabat, Laura E Via, Daniel L Barber

Bio

Anti-PD1 [NIVOR4LALA]

2020 July 01

Atrophy and Death of Nonpeptidergic and Peptidergic Nociceptive Neurons in SIV Infection

Jake A Robinson, Guy Guenthner, Rebecca Warfield, Jessica R Kublin, Mandy D Smith, Masoud Shekarabi, Andrew D Miller, Tricia H Burdo

Am J Pathol

Anti-CD8 alpha [MT807R1]

2020 June 01

T cell-inducing vaccine durably prevents mucosal SHIV infection even with lower neutralizing antibody titers

Prabhu S Arunachalam, Tysheena P Charles, Vineet Joag, Venkata S Bollimpelli, Madeleine K D Scott, Florian Wimmers, Samantha L Burton, Celia C Labranche, Caroline Petitdemange, Sailaja Gangadhara, Tiffany M Styles, Clare F Quarnstrom, Korey A Walter, Thomas J Ketas, Traci Legere, Pradeep Babu Jagadeesh Reddy, Sudhir Pai Kasturi, Anthony Tsai, Bertrand Z Yeung, Shakti Gupta, Mark Tomai, John Vasilakos, George M Shaw, Chil-Yong Kang, John P Moore, Shankar Subramaniam, Purvesh Khatri, David Montefiori, Pamela A Kozlowski, Cynthia A Derdeyn, Eric Hunter, David Masopust, Rama R Amara, Bali Pulendran

Nat Med

Reference rhesus dimeric IgA [b12rA1d]

2020 May 15

Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?

Bruno Reichart, Matthias Längin, Julia Radan, Maren Mokelke, Ines Buttgereit, Jiawei Ying, Ann Kathrin Fresch, Tanja Mayr, Lara Issl, Stefan Buchholz, Sebastian Michel, Reinhard Ellgass, Maks Mihalj, Stefanie Egerer, Andrea Baehr, Barbara Kessler, Elisabeth Kemter, Mayuko Kurome, Valeri Zakhartchenko, Stig Steen, Trygve Sjöberg, Audrius Paskevicius, Luise Krüger, Uwe Fiebig, Joachim Denner, Antonia W Godehardt, Ralf R Tönjes, Anastasia Milusev, Robert Rieben, Riccardo Sfriso, Christoph Walz, Thomas Kirchner, David Ayares, Karen Lampe, Uwe Schönmann, Christian Hagl, Eckhard Wolf, Nikolai Klymiuk, Jan-Michael Abicht, Paolo Brenner

J Heart Lung Transplant

Anti-CD40 [2C10R4]

2020 March 18

Transduction and Expansion of Primary T Cells in Nine Days with Maintenance of Central Memory Phenotype

Mary S. Pampusch, Pamela J. Skinner

JoVe

Anti-CD28 [CD28.2] Anti-CD3 [FN18]

2020 February 13

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies

Nuria Pedreño-Lopez, Christine M Dang, Brandon C Rosen, Michael J Ricciardi, Varian K Bailey, Martin J Gutman, Lucas Gonzalez-Nieto, Matthias G Pauthner, Khoa Le, Ge Song, Raiees Andrabi, Kim L Weisgrau, Nicholas Pomplun, José M Martinez-Navio, Sebastian P Fuchs, Jens Wrammert, Eva G Rakasz, Jeffrey D Lifson, Mauricio A Martins, Dennis R Burton, David I Watkins, Diogo M Magnani

Mol Ther Methods Clin Dev

Anti-CD8 beta [CD8b255R1]

2020 February 01

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 + cells

Julia Bergild McBrien, Maud Mavigner, Lavinia Franchitti, S Abigail Smith, Erick White, Gregory K Tharp, Hasse Walum, Kathleen Busman-Sahay, Christian R Aguilera-Sandoval, William O Thayer, Rae Ann Spagnuolo, Martina Kovarova, Angela Wahl, Barbara Cervasi, David M Margolis, Thomas H Vanderford, Diane G Carnathan, Mirko Paiardini, Jeffrey D Lifson, John H Lee, Jeffrey T Safrit, Steven E Bosinger, Jacob D Estes, Cynthia A Derdeyn, J Victor Garcia, Deanna A Kulpa, Ann Chahroudi, Guido Silvestri

Nature

Anti-CD8 alpha [MT807R1]

2020 January 17

Functional MAIT Cells Are Associated With Reduced Simian–Human Immunodeficiency Virus Infection

Amudhan Murugesan, Chris Ibegbu, Tiffany M Styles, Andrew T Jones, Uma Shanmugasundaram, Pradeep B J Reddy, Sadia J Rahman, Piu Saha, Matam Vijay-Kumar, Esaki Muthu Shankar, Rama Rao Amara, Vijayakumar Velu

Front Immunol

Anti-alpha4/beta7 [A4B7R1]

2020 January 01

Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques – an experimental study

Berglund et al.

Transplant International

Anti-CD2 [LoCD2bR1]

2019 December 01

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

Brian Ezekian, Paul M Schroder, Michael S Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S Yi, Felicitas Smith, Danae Olaso, Frances M Saccoccio, Sallie Permar, Alton B Farris, Jean Kwun, Stuart J Knechtle

J Am Soc Nephrol

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 October 22

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques.

Lo M, Zhu J, Hansen SG, Carroll T, Farr Zuend C, Nöel-Romas L, Ma ZM, Fritts L, Huang ML, Sun S, Huang Y, Koelle DM, Picker LJ, Burgener A, Corey L, Miller CJ

Journal of virology

Anti-CD8 alpha [MT807R1] Anti-IL-15 [IL-15R1LALA]

2019 September 30

Rapid Transduction and Expansion of Transduced T Cells with Maintenance of Central Memory Populations

Mary S. Pampusch, Kumudhini Preethi Haran, Geoffrey T. Hart, Eva G. Rakasz, Aaron K. Rendahl, Edward A. Berger, Elizabeth Connick, and Pamela J. Skinner

Mol Ther Methods Clin Dev

Anti-CD28 [CD28.2] Anti-CD3 [FN18]

2019 September 23

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.

Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB

Science translational medicine

Anti-CD8 alpha [MT807R1] Anti-CD38 [OKT10]-PE

2019 September 06

Lack of therapeutic efficacy of an antibody to α4 β7 in SIVmac251-infected rhesus macaques

Peter Abbink, Noe B Mercado, Joseph P Nkolola, Rebecca L Peterson, Hubert Tuyishime, Katherine McMahan, Edward T Moseley, Erica N Borducchi, Abishek Chandrashekar, Esther A Bondzie, Arshi Agarwal, Aaron J Belli, Keith A Reimann, Brandon F Keele, Romas Geleziunas, Mark G Lewis, Dan H Barouch

Science

Anti-alpha4/beta7 [A4B7R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2019 July 01

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use

Jean Kwun, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, Chantal Gautreau, Brian Ezekian, Diane Bodez, Thibault Damy, Laureline Faivre, Dehbia Menouch, Janghoon Yoon, Jaeberm Park, Karim Belhadj, Dongfeng Chen, Alyssa M Bilewski, John S Yi, Bradley Collins, Mark Stegall, Alton B Farris, Stuart Knechtle, Philippe Grimbert

J Am Soc Nephrol

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 May 19

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Kimberly M Cirelli, Diane G Carnathan, Bartek Nogal, Jacob T Martin, Oscar L Rodriguez, Amit A Upadhyay, Chiamaka A Enemuo, Etse H Gebru, Yury Choe, Federico Viviano, Catherine Nakao, Matthias G Pauthner, Samantha Reiss, Christopher A Cottrell, Melissa L Smith, Raiza Bastidas, William Gibson, Amber N Wolabaugh, Mariane B Melo, Benjamin Cossette, Venkatesh Kumar, Nirav B Patel, Talar Tokatlian, Sergey Menis, Daniel W Kulp, Dennis R Burton, Ben Murrell, William R Schief, Steven E Bosinger, Andrew B Ward, Corey T Watson, Guido Silvestri, Darrell J Irvine, Shane Crotty

Cell

Anti-CD38 [OKT10]-PE

2019 May 13

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound.

Okoye AA, Hansen SG, Vaidya M, Fukazawa Y, Park H, Duell DM, Lum R, Hughes CM, Ventura AB, Ainslie E, Ford JC, Morrow D, Gilbride RM, Legasse AW, Hesselgesser J, Geleziunas R, Li Y, Oswald K, Shoemaker R, Fast R, Bosche WJ, Borate BR, Edlefsen PT, Axthelm MK, Picker LJ, Lifson JD

Nature medicine

Anti-CD8 alpha [MT807R1]

2019 May 01

Operational immune tolerance towards transplanted allogeneic pancreatic islets in mice and a non-human primate

Midhat H Abdulreda, Dora M Berman, Alexander Shishido, Christopher Martin, Maged Hossameldin, Ashley Tschiggfrie, Luis F Hernandez, Ana Hernandez, Camillo Ricordi, Jean-Marie Parel, Ewa Jankowska-Gan, William J Burlingham, Esdras A Arrieta-Quintero, Victor L Perez, Norma S Kenyon, Per-Olof Berggren

Diabetologia

Anti-CD154 [5C8H1]

2019 April 05

Mucosal and systemic SIV-specific cytotoxic CD4+ T cell hierarchy in protection following intranasal/intramuscular recombinant pox-viral vaccination of pigtail macaques.

Khanna, Mayank; Jackson, Ronald J; Alcantara, Sheilajen; Amarasena, Thakshila H; Li, Zheyi; Kelleher, Anthony D; Kent, Stephen J; Ranasinghe, Charani

Scientific Reports

Legacy Product

2019 March 19

A Pathogenic Role for Splenic B1 Cells in SIV Disease Progression in Rhesus Macaques.

Enyindah-Asonye, Gospel; Nwankwo, Anthony; Hogge, Christopher; Rahman, Mohammad Arif; Helmold Hait, Sabrina; Hunegnaw, Ruth; Ko, Eun-Ju; Hoang, Tanya; Venzon, David J; Robert-Guroff, Marjorie

Frontiers in Immunology

Legacy Product

2019 March 01

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients

Christopher K Burghuber, Miriam Manook, Brian Ezekian, Adriana C Gibby, Frank V Leopardi, Minqing Song, Jennifer Jenks, Frances Saccoccio, Sallie Permar, Alton B Farris, Neal N Iwakoshi, Jean Kwun, Stuart J Knechtle

Am J Transplant

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 February 20

Introduction of the YTE mutation into the non-immunogenic HIV bnAb PGT121 induces anti-drug antibodies in macaques.

Rosenberg, Yvonne J; Lewis, George K; Montefiori, David C; LaBranche, Celia C; Lewis, Mark G; Urban, Lori A; Lees, Jonathan P; Mao, Lingjun; Jiang, Xiaoming

PloS One

Legacy Product

2019 February 12

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.

Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH

Nature

Anti-CD8 alpha [MT807R1]

2019 January 17

Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion

Vicki Traina-Dorge, Brent E Palmer, Colin Coleman, Meredith Hunter, Amy Frieman, Anah Gilmore, Karen Altrock, Lara Doyle-Meyers, Maria A Nagel, Ravi Mahalingam

J Virol

Anti-CD4 [CD4R1]

2019 January 01

Hybrid nanocarriers incorporating mechanistically distinct drugs for lymphatic CD4+ T cell activation and HIV-1 latency reversal.

Cao, Shijie; Slack, Sarah D; Levy, Claire N; Hughes, Sean M; Jiang, Yonghou; Yogodzinski, Christopher; Roychoudhury, Pavitra; Jerome, Keith R; Schiffer, Joshua T; Hladik, Florian; Woodrow, Kim A

Science Advances

Anti-CD4 [CD4R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2018 December 17

Differentiation of primate primordial germ cell-like cells following transplantation into the adult gonadal niche.

Sosa, Enrique; Chen, Di; Rojas, Ernesto J; Hennebold, Jon D; Peters, Karen A; Wu, Zhuang; Lam, Truong N; Mitchell, Jennifer M; Sukhwani, Meena; Tailor, Ramesh C; Meistrich, Marvin L; Orwig, Kyle E; Shetty, Gunapala; Clark, Amander T

Nature Communications

Legacy Product

2018 December 10

Subclinical Infection of Macaques and Baboons with A Baboon Simarterivirus.

Buechler, Connor; Semler, Matthew; Baker, David A; Newman, Christina; Cornish, Joseph P; Chavez, Deborah; Guerra, Bernadette; Lanford, Robert; Brasky, Kathy; Kuhn, Jens H; Johnson, Reed F; O'connor, David H; Bailey, Adam L

Viruses

Legacy Product

2018 December 01

Consistent success in life-supporting porcine cardiac xenotransplantation

Matthias Längin, Tanja Mayr, Bruno Reichart, Sebastian Michel, Stefan Buchholz, Sonja Guethoff, Alexey Dashkevich, Andrea Baehr, Stefanie Egerer, Andreas Bauer, Maks Mihalj, Alessandro Panelli, Lara Issl, Jiawei Ying, Ann Kathrin Fresch, Ines Buttgereit, Maren Mokelke, Julia Radan, Fabian Werner, Isabelle Lutzmann, Stig Steen, Trygve Sjöberg, Audrius Paskevicius, Liao Qiuming, Riccardo Sfriso, Robert Rieben, Maik Dahlhoff, Barbara Kessler, Elisabeth Kemter, Mayuko Kurome, Valeri Zakhartchenko, Katharina Klett, Rabea Hinkel, Christian Kupatt, Almuth Falkenau, Simone Reu, Reinhard Ellgass, Rudolf Herzog, Uli Binder, Günter Wich, Arne Skerra, David Ayares, Alexander Kind, Uwe Schönmann, Franz-Josef Kaup, Christian Hagl, Eckhard Wolf, Nikolai Klymiuk, Paolo Brenner, Jan-Michael Abicht

Nature

Anti-CD40 [2C10R4]

2018 November 27

Antibody responses to Zika virus proteins in pregnant and non-pregnant macaques.

Heffron, Anna S; Mohr, Emma L; Baker, David; Haj, Amelia K; Buechler, Connor R; Bailey, Adam; Dudley, Dawn M; Newman, Christina M; Mohns, Mariel S; Koenig, Michelle; Breitbach, Meghan E; Rasheed, Mustafa; Stewart, Laurel M; Eickhoff, Jens; Pinapati, Richard S; Beckman, Erica; Li, Hanying; Patel, Jigar; Tan, John C; O'connor, David H

PloS Neglected Tropical Diseases

Anti-primate IgG [8F1]-biotin

2018 November 02

Dysregulation of Neuronal Cholesterol Homeostasis upon Exposure to HIV-1 Tat and Cocaine Revealed by RNA-Sequencing.

Mohseni Ahooyi, Taha; Shekarabi, Masoud; Torkzaban, Bahareh; Langford, T Dianne; Burdo, Tricia H; Gordon, Jennifer; Datta, Prasun K; Amini, Shohreh; Khalili, Kamel

Scientific Reports

Anti-CD8 alpha [MT807R1]

2018 October 29

Antibody-Mediated CD4 Depletion Induces Homeostatic CD4 + T Cell Proliferation without Detectable Virus Reactivation in Antiretroviral Therapy-Treated Simian Immunodeficiency Virus-Infected Macaques

Nitasha A Kumar, Julia B McBrien, Diane G Carnathan, Maud Mavigner, Cameron Mattingly, Erick R White, Federico Viviano, Steve E Bosinger, Ann Chahroudi, Guido Silvestri, Mirko Paiardini, Thomas H Vanderford

J Virol

Anti-CD4 [CD4R1]

2018 October 25

Evidence for persistence of the SHIV reservoir early after MHC haploidentical hematopoietic stem cell transplantation.

Colonna, Lucrezia; Peterson, Christopher W; Schell, John B; Carlson, Judith M; Tkachev, Victor; Brown, Melanie; Yu, Alison; Reddy, Sowmya; Obenza, Willi M; Nelson, Veronica; Polacino, Patricia S; Mack, Heather; Hu, Shiu-Lok; Zeleski, Katie; Hoffman, Michelle; Olvera, Joe; Furlan, Scott N; Zheng, Hengqi; Taraseviciute, Agne; Hunt, Daniel J; Betz, Kayla; Lane, Jennifer F; Vogel, Keith; Hotchkiss, Charlotte E; Moats, Cassie; Baldessari, Audrey; Murnane, Robert D; English, Christopher; Astley, Cliff A; Wangari, Solomon; Agricola, Brian; Ahrens, Joel; Iwayama, Naoto; May, Andrew; Stensland, Laurence; Huang, Meei-Li W; Jerome, Keith R; Kiem, Hans-Peter; Kean, Leslie S

Nature Communications

Anti-Mamu A*01 [P12]-PE

2018 September 27

Hallmarks of primate lentiviral immunodeficiency infection recapitulate loss of innate lymphoid cells.

Mudd, Joseph C; Busman-Sahay, Kathleen; DiNapoli, Sarah R; Lai, Stephen; Sheik, Virginia; Lisco, Andrea; Deleage, Claire; Richardson, Brian; Palesch, David J; Paiardini, Mirko; Cameron, Mark; Sereti, Irini; Reeves, R Keith; Estes, Jacob D; Brenchley, Jason M

Nature Communications

Anti-CD4 [CD4R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2018 September 05

IDLV-HIV-1 Env vaccination in non-human primates induces affinity maturation of antigen-specific memory B cells.

Blasi, Maria; Negri, Donatella; LaBranche, Celia; Alam, S Munir; Baker, Erich J; Brunner, Elizabeth C; Gladden, Morgan A; Michelini, Zuleika; Vandergrift, Nathan A; Wiehe, Kevin J; Parks, Robert; Shen, Xiaoying; Bonsignori, Mattia; Tomaras, Georgia D; Ferrari, Guido; Montefiori, David C; Santra, Sampa; Haynes, Barton F; Moody, Michael A; Cara, Andrea; Klotman, Mary E

Communications Biology

Legacy Product

2018 September 01

MAdCAM costimulation through Integrin-alpha4/beta7 promotes HIV replication.

Nawaz, Fatima; Goes, Livia R; Ray, Jocelyn C; Olowojesiku, Ronke; Sajani, Alia; Ansari, Aftab A; Perrone, Ian; Hiatt, Joseph; Van Ryk, Donald; Wei, Danlan; Waliszewski, Mia; Soares, Marcelo A; Jelicic, Katija; Connors, Mark; Migueles, Stephen A; Martinelli, Elena; Villinger, Francois; Cicala, Claudia; Fauci, Anthony S; Arthos, James

Mucosal Immunology

2018 August 30

Inhibition of p38 MAPK in combination with ART reduces SIV-induced immune activation and provides additional protection from immune system deterioration.

Chaudhary, Omkar; Narayan, Vivek; Lelis, Felipe; Linz, Brandon; Watkins, Meagan; Veazey, Ronald; Aldovini, Anna

PloS Pathogens

Anti-CD38 [OKT10]-APC

2018 August 28

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha4/beta7.

Lertjuthaporn et al.

PloS Pathogens

Anti-alpha4/beta7 [A4B7R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2018 August 22

Two Vaccines for Staphylococcus aureus Induce a B-Cell-Mediated Immune Response.

Dupont, Christopher D; Scully, Ingrid L; Zimnisky, Ross M; Monian, Brinda; Rossitto, Christina P; O'connell, Ellen B; Jansen, Kathrin U; Anderson, Annaliesa S; Love, J Christopher

MSphere

Anti-CD38 [OKT10]-PE

2018 July 13

Zika convalescent macaques display delayed induction of anamnestic cross-neutralizing antibody responses after dengue infection.

Valiant, William G; Huang, Yan-Jang S; Vanlandingham, Dana L; Higgs, Stephen; Lewis, Mark G; Mattapallil, Joseph J

Emerging Microbes & Infections

Legacy Product

2018 June 01

HIV vaccine candidate activation of hypoxia and the inflammasome in CD14+ monocytes is associated with a decreased risk of SIVmac251 acquisition.

Vaccari, Monica; Fourati, Slim; Gordon, Shari N; Brown, Dallas R; Bissa, Massimilano; Schifanella, Luca; Silva de Castro, Isabela; Doster, Melvin N; Galli, Veronica; Omsland, Maria; Fujikawa, Dai; Gorini, Giacomo; Liyanage, Namal P M; Trinh, Hung V; McKinnon, Katherine M; Foulds, Kathryn E; Keele, Brandon F; Roederer, Mario; Koup, Richard A; Shen, Xiaoying; Tomaras, Georgia D; Wong, Marcus P; Munoz, Karissa J; Gach, Johannes S; Forthal, Donald N; Montefiori, David C; Venzon, David J; Felber, Barbara K; Rosati, Margherita; Pavlakis, George N; Rao, Mangala; Sekaly, Rafick-Pierre; Franchini, Genoveffa

Nature Medicine

Anti-alpha4/beta7 [A4B7R1]-APC

2018 May 11

Temporal/compartmental changes in viral RNA and neuronal injury in a primate model of NeuroAIDS.

González, R Gilberto; Fell, Robert; He, Julian; Campbell, Jennifer; Burdo, Tricia H; Autissier, Patrick; Annamalai, Lakshmanan; Taheri, Faramarz; Parker, Termara; Lifson, Jeffrey D; Halpern, Elkan F; Vangel, Mark; Masliah, Eliezer; Westmoreland, Susan V; Williams, Kenneth C; Ratai, Eva-Maria

PloS One

Anti-CD8 alpha [MT807R1]

2018 May 01

Early treatment of SIV+ macaques with analpha4/beta7 alters virus distribution and preserves CD4+ T cells in later stages of infection.

Santangelo, P J; Cicala, C; Byrareddy, S N; Ortiz, K T; Little, D; Lindsay, K E; Gumber, S; Hong, J J; Jelicic, K; Rogers, K A; Zurla, C; Villinger, F; Ansari, A A; Fauci, A S; Arthos, J

Mucosal Immunology

Anti-alpha4/beta7 [A4B7R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1] Anti-CD4 [OKT4]

2018 April 15

Associations of Simian Immunodeficiency Virus (SIV)-Specific Follicular CD8+ T Cells with Other Follicular T Cells Suggest Complex Contributions to SIV Viremia Control.

Rahman, Mohammad Arif; McKinnon, Katherine M; Karpova, Tatiana S; Ball, David A; Venzon, David J; Fan, Wenjin; Kang, Guobin; Li, Qingsheng; Robert-Guroff, Marjorie

Journal of Immunology (Baltimore, Md. : 1950)

Anti-CXCR5 [710D82.1]-PE

2018 April 05

Emerging diagnostic challenges and characteristics of simian betaretrovirus infections in captive macaque colonies.

Yee JL, Grant R, Van Rompay KK, Kuller L, Carpenter A, Watanabe R, Huebner R, Agricola B, Smedley J, Roberts JA

Journal of medical primatology

Anti-CD8 alpha [MT807R1]

2018 April 01

Long-term Nonhuman Primate Renal Allograft Survival Without Ongoing Immunosuppression in Recipients of Delayed Donor Bone Marrow Transplantation.

Hotta, Kiyohiko; Oura, Tetsu; Dehnadi, Abbas; Boskovic, Svjetlan; Matsunami, Masatoshi; Rosales, Ivy; Smith, Rex N; Colvin, Robert B; Cosimi, A Benedict; Kawai, Tatsuo

Transplantation

Legacy Product

2018 March 28

Simian Varicella Virus Infects Enteric Neurons andalpha4/beta7 Integrin-Expressing Gut-Tropic T-Cells in Nonhuman Primates.

Ouwendijk, Werner J D; Van Veen, Suzanne; Mehraban, Tamana; Mahalingam, Ravi; Verjans, Georges M G M

Viruses

Anti-alpha4/beta7 [A4B7R1]-APC Anti-alpha4/beta7 [A4B7R1]-PE

2018 March 20

Simian Immunodeficiency Virus (SIV)-Specific Chimeric Antigen Receptor-T Cells Engineered to Target B Cell Follicles and Suppress SIV Replication.

Haran, Kumudhini Preethi; Hajduczki, Agnes; Pampusch, Mary S; Mwakalundwa, Gwantwa; Vargas-Inchaustegui, Diego A; Rakasz, Eva G; Connick, Elizabeth; Berger, Edward A; Skinner, Pamela J

Frontiers in Immunology

Anti-CD28 [CD28.2] Anti-CD3 [FN18]

2018 March 01

Selective CD28 Inhibition Modulates Alloimmunity and Cardiac Allograft Vasculopathy in Anti-CD154-Treated Monkeys.

Zhang, Tianshu; Azimzadeh, Agnes M; Sun, Wenji; O'neill, Natalie A; Sievert, Evelyn; Bergbower, Emily; Braileanu, Gheorghe; Burdorf, Lars; Cheng, Xiangfei; Monahan, Thomas; Dahi, Siamak; Harris, Donald G; Rybak, Elana; Welty, Emily; Kronfli, Anthony; Avon, Chris; Pierson, Richard N

Transplantation

Legacy Product

2018 February 28

Impact of Th1 CD4 Follicular Helper T Cell Skewing on Antibody Responses to an HIV-1 Vaccine in Rhesus Macaques

Anil Verma, Brian A Schmidt, Sonny R Elizaldi, Nancy K Nguyen, Korey A Walter, Zoltan Beck, Hung V Trinh, Ashok R Dinasarapu, Yashavanth Shaan Lakshmanappa, Niharika N Rane, Gary R Matyas, Mangala Rao, Xiaoying Shen, Georgia D Tomaras, Celia C LaBranche, Keith A Reimann, David H Foehl, Johannes S Gach, Donald N Forthal, Pamela A Kozlowski, Rama R Amara, Smita S Iyer

J Virol

Anti-rhesus IgG2 [3C10] - Retired Anti-rhesus IgG3 [2G11] - Retired Legacy Product Anti-rhesus IgG1 [ena]

2018 February 16

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

Manook M, Kwun J, Burghuber C, Samy K, Mulvihill M, Yoon J, Xu H, MacDonald AL, Freischlag K, Curfman V, Branum E, Howell D, Farris AB, Smith RA, Sacks S, Dorling A, Mamode N, Knechtle SJ

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Anti-CD8 alpha [MT807R1]

2018 February 02

Pilot Study of Delayed ICOS/ICOS-L Blockade With αCD40 to Modulate Pathogenic Alloimmunity in a Primate Cardiac Allograft Model.

O'neill, Natalie A; Zhang, Tianshu; Braileanu, Gheorghe; Cheng, Xiangfei; Hershfeld, Alena; Sun, Wenji; Reimann, Keith A; Dahi, Sia; Kubicki, Natalia; Hassanein, Wessam; Laird, Christopher; Cimeno, Arielle; Azimzadeh, Agnes M; Pierson, Richard N

Transplantation Direct

Anti-CD40 [2C10R4] Anti-MHC-class I [W6/32]

2018 January 15

Integrinalpha4/beta7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques.

Calenda, Giulia; Keawvichit, Rassamon; Arrode-Brusés, Géraldine; Pattanapanyasat, Kovit; Frank, Ines; Byrareddy, Siddappa N; Arthos, James; Cicala, Claudia; Grasperge, Brooke; Blanchard, James L; Gettie, Agegnehu; Reimann, Keith A; Ansari, Aftab A; Martinelli, Elena

Journal of Immunology (Baltimore, Md. : 1950)

Legacy Product Anti-alpha4/beta7 [A4B7R1] Anti-alpha4/beta7 [A4B7R1]-PE

2018 January 10

Optimization and comparison of CD4-targeting lipid-polymer hybrid nanoparticles using different binding ligands.

Cao, Shijie; Jiang, Yonghou; Levy, Claire N; Hughes, Sean M; Zhang, Hangyu; Hladik, Florian; Woodrow, Kim A

Journal of Biomedical Materials Research. Part A

Anti-CD4 [CD4R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2018 January 10

Maternal HIV-1 Env Vaccination for Systemic and Breast Milk Immunity To Prevent Oral SHIV Acquisition in Infant Macaques.

Eudailey, Joshua A; Dennis, Maria L; Parker, Morgan E; Phillips, Bonnie L; Huffman, Tori N; Bay, Camden P; Hudgens, Michael G; Wiseman, Roger W; Pollara, Justin J; Fouda, Genevieve G; Ferrari, Guido; Pickup, David J; Kozlowski, Pamela A; Van Rompay, Koen K A; De Paris, Kristina; Permar, Sallie R

MSphere

Anti-rhesus IgA [10F12]-biotin

2018 January 01

Pre-clinical results in pig-to-non-human primate islet xenotransplantation using anti-CD40 antibody (2C10R4)-based immunosuppression.

Shin, Jun-Seop; Kim, Jong-Min; Min, Byoung-Hoon; Yoon, Il Hee; Kim, Hyun Je; Kim, Jung-Sik; Kim, Yong-Hee; Kang, Seong-Jun; Kim, Jiyeon; Kang, Hee-Jung; Lim, Dong-Gyun; Hwang, Eung-Soo; Ha, Jongwon; Kim, Sang-Joon; Park, Wan Beom; Park, Chung-Gyu

Xenotransplantation

Anti-CD40 [2C10R4]

2018 January 01

Delayed revascularization of islets after transplantation by IL-6 blockade in pig to non-human primate islet xenotransplantation model.

Min, Byoung-Hoon; Shin, Jun-Seop; Kim, Jong-Min; Kang, Seong-Jun; Kim, Hyun-Je; Yoon, Il-Hee; Park, Su-Kyoung; Choi, Ji-Won; Lee, Min-Suk; Park, Chung-Gyu

Xenotransplantation

Anti-CD40 [2C10R4]

2018 January 01

The Role of MHC-E in T Cell Immunity Is Conserved among Humans, Rhesus Macaques, and Cynomolgus Macaques.

Wu, Helen L; Wiseman, Roger W; Hughes, Colette M; Webb, Gabriela M; Abdulhaqq, Shaheed A; Bimber, Benjamin N; Hammond, Katherine B; Reed, Jason S; Gao, Lina; Burwitz, Benjamin J; Greene, Justin M; Ferrer, Fidel; Legasse, Alfred W; Axthelm, Michael K; Park, Byung S; Brackenridge, Simon; Maness, Nicholas J; McMichael, Andrew J; Picker, Louis J; O'connor, David H; Hansen, Scott G; Sacha, Jonah B

Journal of Immunology (Baltimore, Md. : 1950)

Anti-Mamu A*01 [P12]-PE

2017 December 05

Experimental Oral Herpes Simplex Virus-1 (HSV-1) Co-infection in Simian Immunodeficiency Virus (SIV)-Infected Rhesus Macaques.

Aravantinou, Meropi; Mizenina, Olga; Calenda, Giulia; Kenney, Jessica; Frank, Ines; Lifson, Jeffrey D; Szpara, Moriah; Jing, Lichen; Koelle, David M; Teleshova, Natalia; Grasperge, Brooke; Blanchard, James; Gettie, Agegnehu; Martinelli, Elena; Derby, Nina

Frontiers in Microbiology

Anti-alpha4/beta7 [A4B7R1]-APC

2017 November 13

Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice.

Li X, Huang J, Zhang M, Funakoshi R, Sheetij D, Spaccapelo R, Crisanti A, Nussenzweig V, Nussenzweig RS, Tsuji M

Vaccine

Control antibody rhesus IgG1 (anti-DSP) [DSPR1] Anti-CD8 alpha [MT807R1]

2017 November 10

Allogeneic stem cell transplantation in fully MHC-matched Mauritian cynomolgus macaques recapitulates diverse human clinical outcomes.

Burwitz, Benjamin J; Wu, Helen L; Abdulhaqq, Shaheed; Shriver-Munsch, Christine; Swanson, Tonya; Legasse, Alfred W; Hammond, Katherine B; Junell, Stephanie L; Reed, Jason S; Bimber, Benjamin N; Greene, Justin M; Webb, Gabriela M; Northrup, Mina; Laub, Wolfram; Kievit, Paul; MacAllister, Rhonda; Axthelm, Michael K; Ducore, Rebecca; Lewis, Anne; Colgin, Lois M A; Hobbs, Theodore; Martin, Lauren D; Ferguson, Betsy; Thomas, Charles R; Panoskaltsis-Mortari, Angela; Meyers, Gabrielle; Stanton, Jeffrey J; Maziarz, Richard T; Sacha, Jonah B

Nature Communications

Legacy Product

2017 November 09

CD4+ levels control the odds of induction of humoral immune responses to tracer doses of therapeutic antibodies.

Srinivasula, Sharat; Gabriel, Erin; Kim, Insook; DeGrange, Paula; St Claire, Alexis; Mallow, Candace; Donahue, Robert E; Paik, Chang; Lane, H C; Di Mascio, Michele

PloS One

Anti-CD4 [CD4R1] Anti-CD4 [OKT4]

2017 November 01

Persistent accumulation of gut macrophages with impaired phagocytic function correlates with SIV disease progression in macaques.

Swan, Zachary D; Bouwer, Anthea L; Wonderlich, Elizabeth R; Barratt-Boyes, Simon M

European Journal of Immunology

Anti-alpha4/beta7 [A4B7R1]-APC Anti-alpha4/beta7 [A4B7R1]-PE

2017 November 01

Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.

Vargas-Inchaustegui, Diego A; Helmold Hait, Sabrina; Chung, Hye Kyung; Narola, Jigna; Hoang, Tanya; Robert-Guroff, Marjorie

Journal of Immunology (Baltimore, Md. : 1950)

Legacy Product

2017 November 01

Natural killer cells migrate into and control simian immunodeficiency virus replication in lymph node follicles in African green monkeys.

Huot, Nicolas; Jacquelin, Beatrice; Garcia-Tellez, Thalia; Rascle, Philippe; Ploquin, Mickaël J; Madec, Yoann; Reeves, R Keith; Derreudre-Bosquet, Nathalie; Müller-Trutwin, Michaela

Nature Medicine

Anti-IL-15 [IL-15R1LALA]

2017 October 26

Pegivirus avoids immune recognition but does not attenuate acute-phase disease in a macaque model of HIV infection.

Bailey, Adam L; Buechler, Connor R; Matson, Daniel R; Peterson, Eric J; Brunner, Kevin G; Mohns, Mariel S; Breitbach, Meghan; Stewart, Laurel M; Ericsen, Adam J; Newman, Christina M; Koenig, Michelle R; Mohr, Emma; Tan, John; Capuano, Saverio; Simmons, Heather A; Yang, David T; O'connor, David H

PloS Pathogens

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