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Publications

Publications Using Our Reagents

In addition to maintaining the most robust Resource of nonhuman primate reagents, the community of scientific researchers depend on your published research to validate and guide future use of the reagents. We continue to grow the publication database so that peer-reviewed results can inform future research decisions. If you have recently published a study using an NHPRR reagent, you can now add it directly to the publication database.

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2020 September 05

Preoperative Carfilzomib and Lulizumab based desensitization prolongs graft survival in a sensitized non-human primate model

Paul M Schroder , Robin Schmitz, Zachary W Fitch, Brian Ezekian, Janghoon Yoon, Ashley Y Choi, Miriam Manook, Andrew Barbas, Frank Leopardi, Mingqing Song, Alton B Farris, Bradley Collins, Jean Kwun, Stuart J Knechtle

Kidney Int

Anti-rhesus thymocyte [rhATG3] - Lot 3 (retired)

2020 August 05

PD-1 blockade exacerbates Mycobacterium tuberculosis infection in rhesus macaques

Keith D Kauffman, Shunsuke Sakai, Nickiana E Lora, Sivaranjani Namasivayam, Paul J Baker, Olena Kamenyeva, Taylor W Foreman, Christine E Nelson, Deivide Oliveira-de-Souza, Caian L. Vinhaes, Ziv Yaniv, Cecilia S Lindestam Arleham, Alessandro Sette, Gordon J Freeman, Rashida Moore, the NIAID/DIR Tuberculosis Imaging Program, Alan Sher, Katrin D Mayer-Barber, Bruno B Andrade, Juraj Kabat, Laura E Via, Daniel L Barber

Bio

Anti-PD1 [NIVOR4LALA]

2020 February 13

Induction of Transient Virus Replication Facilitates Antigen-Independent Isolation of SIV-Specific Monoclonal Antibodies

Nuria Pedreño-Lopez, Christine M Dang, Brandon C Rosen, Michael J Ricciardi, Varian K Bailey, Martin J Gutman, Lucas Gonzalez-Nieto, Matthias G Pauthner, Khoa Le, Ge Song, Raiees Andrabi, Kim L Weisgrau, Nicholas Pomplun, José M Martinez-Navio, Sebastian P Fuchs, Jens Wrammert, Eva G Rakasz, Jeffrey D Lifson, Mauricio A Martins, Dennis R Burton, David I Watkins, Diogo M Magnani

Mol Ther Methods Clin Dev

Anti-CD8 beta [CD8b255R1]

2020 February 01

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8 + cells

Julia Bergild McBrien, Maud Mavigner, Lavinia Franchitti, S Abigail Smith, Erick White, Gregory K Tharp, Hasse Walum, Kathleen Busman-Sahay, Christian R Aguilera-Sandoval, William O Thayer, Rae Ann Spagnuolo, Martina Kovarova, Angela Wahl, Barbara Cervasi, David M Margolis, Thomas H Vanderford, Diane G Carnathan, Mirko Paiardini, Jeffrey D Lifson, John H Lee, Jeffrey T Safrit, Steven E Bosinger, Jacob D Estes, Cynthia A Derdeyn, J Victor Garcia, Deanna A Kulpa, Ann Chahroudi, Guido Silvestri

Nature

Anti-CD8 alpha [MT807R1]

2020 January 01

Safety and pharmacodynamics of anti-CD2 monoclonal antibody treatment in cynomolgus macaques – an experimental study

Berglund et al.

Transplant International

Anti-CD2 [LoCD2bR1]

2019 December 01

Pretransplant Desensitization with Costimulation Blockade and Proteasome Inhibitor Reduces DSA and Delays Antibody-Mediated Rejection in Highly Sensitized Nonhuman Primate Kidney Transplant Recipients

Brian Ezekian, Paul M Schroder, Michael S Mulvihill, Andrew Barbas, Bradley Collins, Kyle Freischlag, Janghoon Yoon, John S Yi, Felicitas Smith, Danae Olaso, Frances M Saccoccio, Sallie Permar, Alton B Farris, Jean Kwun, Stuart J Knechtle

J Am Soc Nephrol

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 October 22

Acute Infection and Subsequent Subclinical Reactivation of Herpes Simplex Virus 2 after Vaginal Inoculation of Rhesus Macaques.

Lo M, Zhu J, Hansen SG, Carroll T, Farr Zuend C, Nöel-Romas L, Ma ZM, Fritts L, Huang ML, Sun S, Huang Y, Koelle DM, Picker LJ, Burgener A, Corey L, Miller CJ

Journal of virology

Anti-CD8 alpha [MT807R1]

2019 September 23

TLR7 agonists induce transient viremia and reduce the viral reservoir in SIV-infected rhesus macaques on antiretroviral therapy.

Lim SY, Osuna CE, Hraber PT, Hesselgesser J, Gerold JM, Barnes TL, Sanisetty S, Seaman MS, Lewis MG, Geleziunas R, Miller MD, Cihlar T, Lee WA, Hill AL, Whitney JB

Science translational medicine

Anti-CD8 alpha [MT807R1]

2019 September 06

Lack of therapeutic efficacy of an antibody to α4 β7 in SIVmac251-infected rhesus macaques

Peter Abbink, Noe B Mercado, Joseph P Nkolola, Rebecca L Peterson, Hubert Tuyishime, Katherine McMahan, Edward T Moseley, Erica N Borducchi, Abishek Chandrashekar, Esther A Bondzie, Arshi Agarwal, Aaron J Belli, Keith A Reimann, Brandon F Keele, Romas Geleziunas, Mark G Lewis, Dan H Barouch

Science

Anti-alpha4/beta7 [A4B7R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2019 July 01

Daratumumab in Sensitized Kidney Transplantation: Potentials and Limitations of Experimental and Clinical Use

Jean Kwun, Marie Matignon, Miriam Manook, Soulef Guendouz, Vincent Audard, David Kheav, Elsa Poullot, Chantal Gautreau, Brian Ezekian, Diane Bodez, Thibault Damy, Laureline Faivre, Dehbia Menouch, Janghoon Yoon, Jaeberm Park, Karim Belhadj, Dongfeng Chen, Alyssa M Bilewski, John S Yi, Bradley Collins, Mark Stegall, Alton B Farris, Stuart Knechtle, Philippe Grimbert

J Am Soc Nephrol

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 May 13

Early antiretroviral therapy limits SIV reservoir establishment to delay or prevent post-treatment viral rebound.

Okoye AA, Hansen SG, Vaidya M, Fukazawa Y, Park H, Duell DM, Lum R, Hughes CM, Ventura AB, Ainslie E, Ford JC, Morrow D, Gilbride RM, Legasse AW, Hesselgesser J, Geleziunas R, Li Y, Oswald K, Shoemaker R, Fast R, Bosche WJ, Borate BR, Edlefsen PT, Axthelm MK, Picker LJ, Lifson JD

Nature medicine

Anti-CD8 alpha [MT807R1]

2019 March 01

Dual targeting: Combining costimulation blockade and bortezomib to permit kidney transplantation in sensitized recipients

Christopher K Burghuber, Miriam Manook, Brian Ezekian, Adriana C Gibby, Frank V Leopardi, Minqing Song, Jennifer Jenks, Frances Saccoccio, Sallie Permar, Alton B Farris, Neal N Iwakoshi, Jean Kwun, Stuart J Knechtle

Am J Transplant

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2019 February 12

Antibody and TLR7 agonist delay viral rebound in SHIV-infected monkeys.

Borducchi EN, Liu J, Nkolola JP, Cadena AM, Yu WH, Fischinger S, Broge T, Abbink P, Mercado NB, Chandrashekar A, Jetton D, Peter L, McMahan K, Moseley ET, Bekerman E, Hesselgesser J, Li W, Lewis MG, Alter G, Geleziunas R, Barouch DH

Nature

Anti-CD8 alpha [MT807R1]

2019 January 17

Reactivation of Simian Varicella Virus in Rhesus Macaques after CD4 T Cell Depletion

Vicki Traina-Dorge, Brent E Palmer, Colin Coleman, Meredith Hunter, Amy Frieman, Anah Gilmore, Karen Altrock, Lara Doyle-Meyers, Maria A Nagel, Ravi Mahalingam

J Virol

Anti-CD4 [CD4R1]

2018 August 28

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to alpha4/beta7.

Lertjuthaporn et al.

PloS Pathogens

Anti-alpha4/beta7 [A4B7R1] Control antibody rhesus IgG1 (anti-DSP) [DSPR1]

2018 April 05

Emerging diagnostic challenges and characteristics of simian betaretrovirus infections in captive macaque colonies.

Yee JL, Grant R, Van Rompay KK, Kuller L, Carpenter A, Watanabe R, Huebner R, Agricola B, Smedley J, Roberts JA

Journal of medical primatology

Anti-CD8 alpha [MT807R1]

2018 February 16

Thrombalexin: Use of a Cytotopic Anticoagulant to Reduce Thrombotic Microangiopathy in a Highly Sensitized Model of Kidney Transplantation.

Manook M, Kwun J, Burghuber C, Samy K, Mulvihill M, Yoon J, Xu H, MacDonald AL, Freischlag K, Curfman V, Branum E, Howell D, Farris AB, Smith RA, Sacks S, Dorling A, Mamode N, Knechtle SJ

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Anti-CD8 alpha [MT807R1]

2017 November 13

Human CD8+ T cells mediate protective immunity induced by a human malaria vaccine in human immune system mice.

Li X, Huang J, Zhang M, Funakoshi R, Sheetij D, Spaccapelo R, Crisanti A, Nussenzweig V, Nussenzweig RS, Tsuji M

Vaccine

Anti-CD8 alpha [MT807R1]

2017 October 01

Successful desensitization with proteasome inhibition and costimulation blockade in sensitized nonhuman primates

Jean Kwun, Christopher Burghuber, Miriam Manook, Brian Ezekian, Jaeberm Park, Janghoon Yoon, John S Yi, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Alton B Farris, Allan D Kirk, Stuart J Knechtle

Blood Adv

Anti-CD40 [2C10R4]

2017 September 05

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.

Cartwright EK, Spicer L, Smith SA, Lee D, Fast R, Paganini S, Lawson BO, Nega M, Easley K, Schmitz JE, Bosinger SE, Paiardini M, Chahroudi A, Vanderford TH, Estes JD, Lifson JD, Derdeyn CA, Silvestri G

Immunity

Anti-CD8 alpha [MT807R1]

2017 July 01

Humoral Compensation after Bortezomib Treatment of Allosensitized Recipients

Jean Kwun, Christopher Burghuber, Miriam Manook, Neal Iwakoshi, Adriana Gibby, Jung Joo Hong, Stuart Knechtle

J Am Soc Nephrol

Anti-CD38 [OKT10]-APC

2017 June 23

Multi-dose Romidepsin Reactivates Replication Competent SIV in Post-antiretroviral Rhesus Macaque Controllers.

Policicchio BB, Xu C, Brocca-Cofano E, Raehtz KD, He T, Ma D, Li H, Sivanandham R, Haret-Richter GS, Dunsmore T, Trichel A, Mellors JW, Hahn BH, Shaw GM, Ribeiro RM, Pandrea I, Apetrei C

PLoS pathogens

Anti-CD8 alpha [MT807R1]

2016 August 26

Early short-term treatment with neutralizing human monoclonal antibodies halts SHIV infection in infant macaques.

Hessell AJ, Jaworski JP, Epson E, Matsuda K, Pandey S, Kahl C, Reed J, Sutton WF, Hammond KB, Cheever TA, Barnette PT, Legasse AW, Planer S, Stanton JJ, Pegu A, Chen X, Wang K, Siess D, Burke D, Park BS, Axthelm MK, Lewis A, Hirsch VM, Graham BS, Mascola JR, Sacha JB, Haigwood NL

Nature medicine

Anti-CD8 alpha [MT807R1]

2016 August 15

Effect of Anti-IL-15 Administration on T Cell and NK Cell Homeostasis in Rhesus Macaques.

Maren Q DeGottardi, Afam A Okoye, Mukta Vaidya, Aarthi Talla, Audrie L Konfe, Matthew D Reyes, Joseph A Clock, Derick M Duell, Alfred W Legasse, Amit Sabnis, Byung S Park, Michael K Axthelm, Jacob D Estes, Keith A Reiman, Rafick-Pierre Sekaly, Louis J Picker

J Immunol

Anti-IL-15 [IL-15R1LALA]

2016 June 06

HIV Replication Is Not Controlled by CD8+ T Cells during the Acute Phase of the Infection in Humanized Mice.

Petit NY, Lambert-Niclot S, Marcelin AG, Garcia S, Marodon G

PloS one

Anti-CD8 alpha [MT807R1]

2016 June 01

Antibody-Mediated Rejection in Sensitized Nonhuman Primates: Modeling Human Biology

C K Burghuber, J Kwun, E J Page, M Manook, A C Gibby, F V Leopardi, M Song, A B Farris 3rd, J J Hong, F Villinger, A B Adams, N N Iwakoshi, S J Knechtle

Am J Transplant

Anti-CD4 [CD4R1] Anti-CD8 alpha [MT807R1]

2015 September 29

Early Initiation of Antiretroviral Therapy Can Functionally Control Productive HIV-1 Infection in Humanized-BLT Mice.

Li Q, Tso FY, Kang G, Lu W, Li Y, Fan W, Yuan Z, Destache CJ, Wood C

Journal of acquired immune deficiency syndromes (1999)

Anti-CD8 alpha [MT807R1]

2015 June 16

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins.

Del Prete GQ, Ailers B, Moldt B, Keele BF, Estes JD, Rodriguez A, Sampias M, Oswald K, Fast R, Trubey CM, Chertova E, Smedley J, LaBranche CC, Montefiori DC, Burton DR, Shaw GM, Markowitz M, Piatak M, KewalRamani VN, Bieniasz PD, Lifson JD, Hatziioannou T

Cell host & microbe

Anti-CD8 alpha [MT807R1]

2015 April 09

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers.

Fukazawa Y, Lum R, Okoye AA, Park H, Matsuda K, Bae JY, Hagen SI, Shoemaker R, Deleage C, Lucero C, Morcock D, Swanson T, Legasse AW, Axthelm MK, Hesselgesser J, Geleziunas R, Hirsch VM, Edlefsen PT, Piatak M, Estes JD, Lifson JD, Picker LJ

Nature medicine

Anti-CD8 alpha [MT807R1]

2015 March 11

Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia.

Gordon SN, Doster MN, Kines RC, Keele BF, Brocca-Cofano E, Guan Y, Pegu P, Liyanage NP, Vaccari M, Cuburu N, Buck CB, Ferrari G, Montefiori D, Piatak M, Lifson JD, Xenophontos AM, Venzon D, Robert-Guroff M, Graham BS, Lowy DR, Schiller JT, Franchini G

Journal of immunology (Baltimore, Md. : 1950)

Anti-CD8 alpha [MT807R1]

2015 March 01

Neutralizing BAFF/APRIL with atacicept prevents early DSA formation and AMR development in T cell depletion induced nonhuman primate AMR model

J Kwun, E Page, J J Hong, A Gibby, J Yoon, A B Farris, F Villinger, S Knechtle

Am J Transplant

Anti-CD3 [C207]-Diphtheria Toxin

2014 January 22

Rhesus macaques vaccinated with consensus envelopes elicit partially protective immune responses against SHIV SF162p4 challenge.

Eugene HS, Pierce-Paul BR, Cragio JK, Ross TM

Virology journal

Anti-CD8 alpha [MT807R1]

2014 January 01

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection

E J Kim , J Kwun, A C Gibby, J J Hong, A B Farris 3rd, N N Iwakoshi, F Villinger, A D Kirk, S J Knechtle

Am J Transplant

Anti-CD40 [2C10R4]

2014 January 01

Costimulation blockade alters germinal center responses and prevents antibody-mediated rejection

E J Kim, J Kwun, A C Gibby, J J Hong, A B Farris 3rd, N N Iwakoshi, F Villinger, A D Kirk, S J Knechtle

Am J Transplant

Anti-CD3 [C207]-Diphtheria Toxin

2013 November 08

Immune clearance of highly pathogenic SIV infection.

Hansen SG, Piatak M, Ventura AB, Hughes CM, Gilbride RM, Ford JC, Oswald K, Shoemaker R, Li Y, Lewis MS, Gilliam AN, Xu G, Whizin N, Burwitz BJ, Planer SL, Turner JM, Legasse AW, Axthelm MK, Nelson JA, Früh K, Sacha JB, Estes JD, Keele BF, Edlefsen PT, Lifson JD, Picker LJ

Nature

Anti-CD8 alpha [MT807R1]

2012 September 01

Enhanced de novo alloantibody and antibody-mediated injury in rhesus macaques

E K Page, A J Page, J Kwun, A C Gibby, F Leopardi, J B Jenkins, E A Strobert, M Song, R A Hennigar, N Iwakoshi, S J Knechtle

Am J Transplant

Anti-CD3 [C207]-Diphtheria Toxin

2011 August 25

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

Watkins JD, Siddappa NB, Lakhashe SK, Humbert M, Sholukh A, Hemashettar G, Wong YL, Yoon JK, Wang W, Novembre FJ, Villinger F, Ibegbu C, Patel K, Corti D, Agatic G, Vanzetta F, Bianchi S, Heeney JL, Sallusto F, Lanzavecchia A, Ruprecht RM

PloS one

Anti-CD8 alpha [MT807R1]

2009 July 01

Preliminary in vivo efficacy studies of a recombinant rhesus anti-alpha(4)beta(7) monoclonal antibody

L E Pereira, N Onlamoon, X Wang, R Wang, J Li, K A Reimann, F Villinger, K Pattanapanyasat, K Mori, A A Ansari

Cell Immunol

Anti-alpha4/beta7 [A4B7R1]

2008 June 02

Use of an anti-CD16 antibody for in vivo depletion of natural killer cells in rhesus macaques.

Elisa I Choi, Rijian Wang, Lauren Peterson, Norman L Letvin, Keith A Reimann

Immunology

Anti-CD16 [3G8]
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The Nonhuman Primate Reagent Resource (NHPRR) is a nonprofit laboratory established in 1999, and supported by the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), and Office of Research Infrastructure Programs (ORIP).

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