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Anti-FcRn [RozR1LALA]

Product Type: Therapeutics (In Vivo)
Format: Anti-FcRn, Roz, rhesusized rat variable region, rhesus IgG1 LALA Fc
Clone ID: [RozR1LALA]
RRID: AB_2888630
Common Names: Anti-FcRn [RozR1LALA] | RozR1LALA | rozanolixizumab | NHP29 | PR-0001
Target: FcRn
Reactivity: Rhesus Macaque (Macaca mulatta) Cynomolgus Monkey (Macaca fascicularis)
Applications: in vivo

RozR1LALA: Rhesus recombinant, humanized, effector-silenced IgG1-kappa anti-FcRn antibody. Derived from rozanolixizumab.

Effect of a single dose of rhesus anti-FcRn mAb (30mg/kg IV, n=6) on circulating total IgG levels. (A) Total serum IgG concentration for individual animals (left). Total IgG level was reduced after anti-FcRn mAb treatment. PMID 34149698

Because of the mechanism of action of this mAb (blocking IgG recycling), you should expect a reduced half-live for all antibodies during aFcRn therapy (a dose of 10mg is washed out in ~3 days).

Modifications: None
Restrictions: No
Sponsor: NIAID
How to cite (Methods): “The rhesus IgG1 Anti-FcRn [RozR1LALA] was provided by the Nonhuman Primate Reagent Resource (NIH Nonhuman Primate Reagent Resource Cat# PR-0001, RRID:AB_2888630)”
How to cite (Acknowledgments): "The Anti-FcRn [RozR1LALA] used in this study was provided by the NIH Nonhuman Primate Reagent Resource (U24 AI126683).”

Reagent cost, which is the actual cost of production, is recovered for some reagents. Please inquire if you have questions about reagent cost recovery. Purchase order or credit card is NOW REQUIRED for cost-recovered reagents.

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