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Anti-FcRn [RozR1LALA]

Anti-FcRn [RozR1LALA]
Product Type: Therapeutics (In Vivo)
Format: Anti-FcRn, Roz, rhesusized rat variable region, rhesus IgG1 LALA Fc
Clone ID: [RozR1LALA]
RRID: AB_2888630
Common Names: Anti-FcRn [RozR1LALA] | RozR1LALA | rozanolixizumab | NHP29 | PR-0001
Target: FcRn
Reactivity: Rhesus Macaque (Macaca mulatta) Cynomolgus Monkey (Macaca fascicularis)
Applications: in vivo
Description:

RozR1LALA: Rhesus recombinant, humanized, effector-silenced IgG1-kappa anti-FcRn antibody. Derived from rozanolixizumab.

Effect of a single dose of rhesus anti-FcRn mAb (30mg/kg IV, n=6) on circulating total IgG levels. (A) Total serum IgG concentration for individual animals (left). Total IgG level was reduced after anti-FcRn mAb treatment. PMID 34149698

Because of the mechanism of action of this mAb (blocking IgG recycling), you should expect a reduced half-live for all antibodies during aFcRn therapy (a dose of 10mg is washed out in ~3 days).
Modifications: None
Restrictions: No
Sponsor: NIAID
How to cite (Methods): “The rhesus IgG1 Anti-FcRn [RozR1LALA] was provided by the Nonhuman Primate Reagent Resource (NIH Nonhuman Primate Reagent Resource Cat# PR-0001, RRID:AB_2888630)”
How to cite (Acknowledgments): "The Anti-FcRn [RozR1LALA] used in this study was provided by the NIH Nonhuman Primate Reagent Resource (U24 AI126683).”

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The Nonhuman Primate Reagent Resource (NHPRR) is a nonprofit laboratory established in 1999, and supported by the National Institutes of Health (NIH), National Institute of Allergy and Infectious Diseases (NIAID), and Office of Research Infrastructure Programs (ORIP).

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