Overview:

Our new reference reagent, rhesus dimeric IgA (CAT-00429), is recombinantly produced in the dimeric form via association with a rhesus J chain. This reagent serves as a reference standard for quantifying anti-IgA responses in nonhuman primate studies, particularly in the context of HIV antibody research. It replaces the former reference reagent based on the b12 clone, providing an updated and more relevant standard for IgA immune response assessments.

Key Features:

• Dimeric rhesus IgA [DRA] Format: Recombinantly produced to ensure proper assembly with a rhesus J chain, mimicking the natural structure of secretory IgA.

• HIV-Specific Targeting: Incorporates the PGT121-derived antigen-binding domain, maintaining HIV-binding specificity.

• Designed for Immune Response Quantitation: Engineered for assays measuring anti-IgA responses, particularly in vaccine and therapeutic antibody studies.

•  Closest Identity to Rhesus IGHA*04 Allele: Engineered matching the rhesus IGHA*04 allele (AY039248 / Strain RWy2.1).

•  Updated Reference Standard: Replaces the former b12-based IgA reagent, ensuring a more relevant tool for evaluating IgA-targeted immunity in rhesus macaques.

• Also Available in a Monomeric Form: For studies requiring a monomeric IgA format, see CAT-00428: Rhesus Monomeric IgA aHIV [PGT121MRA].